2013 Fiscal Year Final Research Report
Pharmacological analysis of antispasmogenic with wire myograph
| Project/Area Number |
24659784
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Plastic surgery
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TERASHI Hiroto 神戸大学, 医学部附属病院, 教授 (80217421)
HASHIKAWA Kazunobu 神戸大学, 医学部附属病院, 准教授 (90403237)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | マイクロサージェリー学 / 血管生理学 |
|---|
| Research Abstract |
To avoid the vascular spasm during microvascular surgery for free tissue transfer, lidocaine has been widely used. On the other hand, the proper concentration of lidocaine is unknown. We introduced wire-myograph system for pharmacological and physiological analysis of lidocaine or other substances for its anti-spasmogenic activity. We examined papaverine hydrochloride, phentolamine messmate, olprinone hydrochloride, nitroglycerine, and prostaglandin E1. On the result, those substances, except prostaglandin E1, showed concentration-dependent anti-spasmogenic activity. On the other hand, prostaglandin E1 showed concentration-dependent spasmogenic activity which may be caused by inflammatory activity. In conclusion, those substances may be used for anti-spasmogenic agent during microsurgical operation.
|
