2015 Fiscal Year Final Research Report
Experimental studies to achieve the oxygenation of ischemic tissue and organs by immersing into oxygenated liquid.
| Project/Area Number |
24659788
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | パーフルオロケミカル / 組織酸素化 / 局所酸素療法 / 創傷治癒 / 臓器保存 / 再生医療 |
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| Outline of Final Research Achievements |
The purpose of this study is to achieve the oxygenation of ischemic tissue and organs by immersing into hyperbaric oxygenated Perfluorochemicals (PFC) which are organic fluorine compound having a high oxygen dissolved capacity, and development of local oxygen therapy with a new approach that does not pass through the blood flow.
We prepared hyperbaric oxygenated PFC under 5 atm pressures of oxygen. This liquid maintained a high partial pressure of oxygen under the normal temperature atmospheric pressure for a long time. Ulcer surface of the rat lower limb was oxygenated by immersing directly into this liquid. When rat skin graft after preservation in hyperbaric oxygenated PFC was transplanted, improvement of tissue preservation ability and engraftment rate, and the promotion of wound healing has been shown equivalent to the UW solution. There was no occurrence of ulcer and neoplasm by follow-up in more than 6 months after transplantation.
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| Free Research Field |
医歯薬学
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