2013 Fiscal Year Final Research Report
Challenge for SHED-based Hematopoietic Regeneration
| Project/Area Number |
24659815
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZA Haruyoshi 九州大学, 大学院歯学研究院, 講師 (30336151)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 乳歯幹細胞 / 造血機能 / 再生医療 / エリスロポイエチン |
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| Research Abstract |
Erythropoietin (EPO) Receptor was expressed on stem cells from human exfoliated deciduous teeth (SHED). EPO-stimutated SHED unregulated Stat5 phospholiration. EPO-stimulated SHED were capable of increasing the formation of hematopietic niches compared to non-stimulated SHED when SHED were subcutanously transplanted with hydroxyapatite carriers into immunocompromised mice. In the increase hematopoietic niche, hematopoietic cells were found by immunofluorescent and flow cytometric analyses. Taken together, these data suggested that EPO is able to induce the capacity of hematopoiesis through SHED.
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[Presentation] Long-term cryopreserved dental pulp tissues of exfoliated deciduous teeth utilize for a feasible stem cell source for regenerative medicine2012
Author(s)
Lan Ma, Yusuke Makino, Haruyoshi Yamaza, Kentaro Akiyama, Yoshihiro Hoshino, Guangtai Song, Toshio Kukita, Kazuaki Nonaka, Songtao Shi, Takayoshi Yamaza
Organizer
Gordon Research Conference, Biometarials & Tissue Engineering
Place of Presentation
Holderness, NH, USA(ポスター発表)
Year and Date
20120728-0802
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