2014 Fiscal Year Final Research Report
Signaling dynamics of inflammatory cellular responses in the activation of pothogenic bone destruction program
Project/Area Number |
24659822
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
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Research Institution | Kyoto University |
Principal Investigator |
ASAGIRI MASATAKA 京都大学, 医学(系)研究科(研究院), 准教授 (20372435)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | 関節リウマチ / 免疫学 / 病理学 / 自己免疫 / 炎症 / 転写因子 / 組織破壊 / 骨代謝 |
Outline of Final Research Achievements |
Cells regulate activation programs through an complex network of molecular interactions. Genome-wide analyses and gene-targeting studies unveiled evidence that inflammatory cytokines influence bone cells via inflammatory transcription factors e.g., nuclear factor (NF)-κB. Stimulation with antigen and IgE activates NF-κB in mast cells. In the present research, we studied the role of NF-κB on cellular migration using the NF-κB inhibitor (–)-DHMEQ. (–)-DHMEQ inhibited antigen/IgE-induced expressions of IL-6 and TNF-α and lowered the expression of matrix metalloproteinase (MMP-2) resulting in the inhibition of invasion toward the antigen. Successful results of the dynamic analyses may reveal a mechanism that underlies the role of inflammation in bone metabolism and have promise as a strategy for exploring drug targets of a variety of bone diseases.
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Free Research Field |
免疫病理学
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