2013 Fiscal Year Final Research Report
Role of oral bacteria on hepatitis
| Project/Area Number |
24659823
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
WADA Koichiro 大阪大学, 歯学研究科(研究院), 准教授 (90263467)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Atsushi 横浜市立大学, 附属病院, 教授 (30326037)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 肝炎 / 口腔細菌 / LPS / NASH / 患者 / マウス / 脂肪蓄積 / レプチン |
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| Research Abstract |
We investigated the role of oral bacteria-related substances on the development of nonalcoholic steatohepatitis (NASH). We found that P. gingivalis-related substances such as lipopolysaccharide (LPS) induced the pathogenesis of NASH on mice under high-fat diet condition. We found the potential mechanisms about the high-fat diet-induced and LPS-stimulated NASH on mice like that leptin-mediated hypersensitivity against LPS was involved in the mechanism. These findings are very important for the prevention of NASH, and we reported such findings to many high-level journals such as "Cell Metabolism".
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[Journal Article] Oral choline tolerance test as a novel noninvasive method for predicting nonalcoholic steatohepatitis2014
Author(s)
Imajo K, Yoneda M, Fujita K, Kessoku T, Tomeno W, Ogawa Y, Shinohara Y, Sekino Y, Mawatari H, Nozaki Y, Kirikoshi H, Taguri M, Toshima G, Takahashi J, Saito S, Wada K, Nakajima A
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Journal Title
Journal of Gastroenterology
Volume: 49
Pages: 295-304
DOI
Peer Reviewed
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[Journal Article] Soluble CD14 levels reflect liver inflammation in patients with nonalcoholic steatohepatitis2013
Author(s)
Ogawa Y, Imajo K, Yoneda M, Kessoku T, Tomeno W, Shinohara Y, Kato S, Mawatari H, Nozaki Y, Fujita K, Kirikoshi H, Maeda S, Saito S, Wada K, Nakajima A
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Journal Title
PLoS One
Volume: 8(6)
Pages: 65211
DOI
Peer Reviewed
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[Journal Article] Plasma free choline is a novel non-invasive biomarker for early-stage non-alcoholic steatohepatitis : A multi-center validation study2012
Author(s)
Imajo K, Fujita K, Yoneda M, Shinohara Y, Suzuki K, Mawatari H, Takahashi J, Nozaki Y, Sumida Y, Kirikoshi H, Saito S, Nakamuta M, Matsuhashi N, Wada K, Nakajima A
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Journal Title
Hepatology Research
Volume: 42
Pages: 757-766
DOI
Peer Reviewed
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[Journal Article] Peroxisome proliferator-activated receptor gamma exacerbates Concanavalin A-induced liver injury via suppressing the translocation of NF-kB into the nucleus2012
Author(s)
Ogawa Y, Yoneda M, Tomeno W, Imajo K, Shinohara Y, Fujita K, Shibata W, Kirikoshi H, Saito S, Wada K, Maeda S, Nakajima A
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Journal Title
PPAR Research
Volume: 2012
Pages: 940384
DOI
Peer Reviewed
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[Journal Article] Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling2012
Author(s)
Imajo K, Fujita K, Yoneda M, Nozaki Y, Ogawa Y, Shinohara Y, Kato S, Mawatari H, Shibata W, Kitani H, Ikejima K, Kirikoshi H, Nakajima N, Saito S, Maeyama S, Watanabe S, Wada K, Nakajima A
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Journal Title
Cell Metabolism
Volume: 16
Pages: 44-54
DOI
Peer Reviewed
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[Presentation] Resveratrol improves pathogenesis of nonalcoholic steatohepatitis through inhibition of endotoxin-induced liver damage2013
Author(s)
Kessoku T, Imajo K, Tomeno W, Ogawa Y, Mawatari H, Yoneda M, Kirikoshi H, Saito S, Wada K, Nakajima A
Organizer
The 64th Annual Meeting of the American Association for the Study of Liver Diseases : The Liver Meeting 2013
Place of Presentation
Washington DC, USA
Year and Date
20131101-05
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[Presentation] Small dense low-density lipoprotein as a useful biomarker for predicting arteriosclerotic diseases in nonalcoholic steatohepatitis2013
Author(s)
Imajo K, Yoneda M, Kessoku T, Tomeno W, Ogawa Y, Mawatari H, Kirikoshi H, Sumida Y, Hyogo H, Eguchi Y, Wada K, Nakajima A
Organizer
The 64th Annual Meeting of the American Association for the Study of Liver Diseases : The Liver Meeting 2013
Place of Presentation
Washington DC, USA
Year and Date
20131101-05
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[Presentation] Association between estrogen receptor alpha gene polymorphism and development of nonalcoholic fatty liver disease (NAFLD)2012
Author(s)
Imajo K, Hotta K, Yoneda M, Kessoku T, Ogawa Y, Shinohara Y, Suzuki K, Shibata W, Kirikoshi H, Saito S, Wada K, Nakajima A
Organizer
The 63rd Annual Meeting of the American Association for the Study of Liver Diseases : The Liver Meeting 2012
Place of Presentation
Boston, USA
Year and Date
20121109-13
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