2013 Fiscal Year Final Research Report
Establishment of a novel screening system to isolate PTH-like osteogenic small compounds
| Project/Area Number |
24659824
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
NISHIMURA Riko 大阪大学, 歯学研究科(研究院), 教授 (60294112)
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| Co-Investigator(Kenkyū-buntansha) |
HATA Kenji 大阪大学, 大学院歯学研究科, 准教授 (80444496)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | PTH / 骨形成 / スクリーニング |
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| Research Abstract |
Parathyroid hormone (PTH) has been shown to be a effective therapeutic agents for bone diseases such as osteoporosis. However, PTH has two major problems; high cost and limitation of term due to its possible side effect. Thus, we have attempted to contribute to development of screening systems that can allow us to explore the small compounds to mimic osteogenic action of PTH. We found that an osteoblastic cell line, SaOS2, is useful and suitable for the screening system. We also attempted to identify the target genes of PTH. Our data suggest that Wnt5a would be a target gene of PTH during bone formation. Our study suggest that a screening system in which we can determine the Wnt5a gene promoter activity would be helpful for developing the therapeutic bone forming small compounds.
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Pages: 1-12
DOI
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Nature Communications
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DOI
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