2013 Fiscal Year Final Research Report
The study of the molecular bases on differences in salt taste sensitivity, palatability and saliva component induced by low or high sodium diet
| Project/Area Number |
24659828
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 口腔生理 / 味覚 / ENaC / アンジオテンシン / アルドステロン |
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| Research Abstract |
Salty taste is a crucial sense for detecting essential minerals, especially sodium ions in the environment and influences sodium intake. Angiotensin II is a key hormone that regulates sodium homeostasis. This study demonstrated that Angiotensin II suppresses amiloride-sensitivity of the mouse gustatory and behavioral responses to NaCl via its receptor AT1 expressed in taste cells. Interestingly, significant increases of taste nerve responses to sweeteners were also observed after the Angiotensin II administration, without effects on the responses to sour, bitter and umami tastants. These results suggest that the regulatory mechanisms by Angiotensin II on the salt and sweet taste sensitivities may exist in peripheral taste organs, contribute to salt and calorie intake, and play important roles in sodium and glucose homeostasis.
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[Presentation] ホルモンによる塩味および甘味感受性調節2014
Author(s)
重村憲徳, 吉田竜介, 安松啓子, 大栗弾宏, 岩田周介, 高井信吾, 上瀧将史, 仁木麻由, 實松敬介, 二ノ宮裕三
Organizer
第91回日本生理学会大会
Place of Presentation
鹿児島(審査有, 口頭)
Year and Date
20140300
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[Presentation] ホルモンによる味覚修飾と摂食調節2013
Author(s)
重村憲徳, 吉田竜介, 安松啓子, 大栗弾宏, 岩田周介, 高井信吾, 上瀧将史, 仁木麻由, 實松敬介, 二ノ宮裕三
Organizer
日本味と匂学会第47回大会
Place of Presentation
仙台(審査有, 口頭)
Year and Date
20130900
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