2013 Fiscal Year Final Research Report
Identification and functional analysis of a novel substrate of Pdk4 in the regulation of osteoclastogenesis in the unloaded condition
| Project/Area Number |
24659829
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
KOMORI Toshihisa 長崎大学, 医歯(薬)学総合研究科, 教授 (00252677)
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| Co-Investigator(Kenkyū-buntansha) |
MORIISHI Takeshi 長崎大学, 大学院医歯薬学総合研究科, 助教 (20380983)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 骨細胞 / 破骨細胞 / 廃用性骨粗鬆症 / メカニカルストレス / Pdk4 |
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| Research Abstract |
Bone mass is increase by exercise and reduced by long-term bed rest, immobilization caused by nerve injury, and microgravity in the space. These non-weight bearing conditions cause disuse osteoporosis. Osteocyte network, which is embedded in bone, is responsible for the sensing of mechanical stress and the transduction of the signal to osteoblasts and osteoclasts in the bone surface, and regulates bone mass. Pdk4, which is a kinase that inhibits energy production in mitochondria, was upregulated in osteoblasts and osteocytes in the unloaded condition of adult mice. Bone loss in the unloaded condition was not caused in Pdk4 adult knockout mice, indicating that Pdk4 is involved in bone loss in the unloaded condition of adult mice.
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[Journal Article] Pin1-mediated Runx2 modification is critical for skeletal development2013
Author(s)
Yoon WJ, Islam R, Cho YD, Woo KM, Baek JH, Uchida T, Komori T, van Wijnen A,Stein JL, Lian JB, Stein GS, Choi JY, Bae SC, Ryoo HM
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Journal Title
J Cell Physiol
Volume: Vol.228
Pages: 2377-85
Peer Reviewed
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[Journal Article] Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53dependent apoptosis without enhancing proliferation2013
Author(s)
Ito K, Maruyama Z, Sakai A, Izumi S, Moriishi T, Yoshida CA, Miyazaki T, Komori H, Takada K, Kawaguchi H, Komori T
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Journal Title
Oncogene
Volume: Vol.33
Pages: 1862-71
Peer Reviewed
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