2013 Fiscal Year Final Research Report
The development of new available autoimmune marker of Sjogren's syndrome for confirmed diagnosis and prognosis
| Project/Area Number |
24659839
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ARAKAKI Rieko 徳島大学, ヘルスバイオサイエンス研究部, 助教 (00193061)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 自己免疫疾患 / シェーグレン症候群 / 自己免疫マーカー / 確定診断 / 予後診断 |
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| Research Abstract |
Autoimmune diseases occur due to autoimmune responses of an individual to self-antigens by the disturbance of self-tolerance. The autoimmune disease patients are increasing year by year, and the QOL decreases in the autoimmune diseases patients all over the world. However the diagnostic method based on an etiology of autoimmune disease has not been established. We have studied for mechanism of the onset of Sjogren`s syndrome experimental model mice and serum, saliva and tear sample of the patients. We analyze the precise mechanism of the onset of Sjogren`s syndrome, and developed the new available autoimmune marker for diagnosis and prognosis.
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[Journal Article] Fas-Independent T-Cell Apoptosis by Dendritic Cells Controls Autoimmune Arthritis in MRL/lpr Mice2012
Author(s)
Takashi Izawa, Tomoyuki Kondo, Mie Kurosawa, Ritsuko Oura, Kazuma Matsumoto, Eiji Tanaka, Akiko Yamada, Rieko Arakaki, Yasusei Kudo, Yoshio Hayashi and Naozumi Ishimaru
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Journal Title
PLoS ONE
Volume: Vol.7, No.12
Pages: e48798
DOI
Peer Reviewed
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