2013 Fiscal Year Final Research Report
Development of biopolymer compound to elucidate the effect of glucan on innate immune system
| Project/Area Number |
24659841
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARIYOSHI Wataru 九州歯科大学, 歯学部, 准教授 (40405551)
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| Co-Investigator(Renkei-kenkyūsha) |
OKINAGA Toshinori 九州歯科大学, 歯学部, 助教 (60582773)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | マクロファージ / β1-3グルカン / dectin-1 / インフラマソーム |
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| Research Abstract |
Several immune system cell-surface receptors are reported to be associated with osteoclastogenesis. Dectin-1, a lectin receptor for beta-glucan, is found predominantly on cells of the myeloid lineage. In the present study, we examined the effect of dectin-1 agonist, curdlan, on osteoclastogenesis. In dectin-1 over-expressing RAW 264.7 cells (d-RAW), curdlan suppressed receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced osteoclast differentiation, bone resorption and actin-ring formation. Furthermore, curdlan inhibited RANKL-induced nuclear factor of activated T-cell cytoplasmic 1 (NFATc1) expression.
In conclusion, our results demonstrate that curdlan potentially inhibits osteoclast differentiation, especially NFATc1 expression. This suggests activation of curdlan-dectin-1 interaction critically regulates the genes required for osteoclastogenesis.
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Research Products
(55 results)
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[Journal Article] Factors associated with dry mouth in dependent Japanese elderly2014
Author(s)
Kakudate N, Muramatsu T, Endoh M, Satomura K, Koseki T, Sato Y, Ito K, Ogasawara T, Nakamura S, Kishimoto E, Kashiwazaki H Yamashita Y, Uchiyama K, Nishihara T, Kiyohara Y, Kakinoki Y
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Journal Title
Gerodontology
Volume: 31(1)
Pages: 11-18
DOI
Peer Reviewed
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[Journal Article] Lipopolysaccharide of Aggregatibacter actinomycetemcomi- tans upregulates inflammatory cytokines, PGE2 synthesis, and osteoclast formation in IL-1Ra deficient mice2013
Author(s)
Mizutani H, Ishihara Y, Izawa A, Fujihara Y, Kobayashi S, Gotou H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Kamei H, Kikuchi T, Yamamoto G, Mitani A, Nishihara T, Noguchi T
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Journal Title
J Periodont Res
Volume: 48(6)
Pages: 748-756
DOI
Peer Reviewed
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