Fabrication of dental pulp-like tissue using 3D cell construct

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659846
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Osaka University
• Principal Investigator: IMAZATO Satoshi 大阪大学, 歯学研究科(研究院), 教授 (80243244)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Takuya 岡山大学, 医歯薬学総合研究科, 教授 (40324793) ; SASAKI Jun-ichi 大阪大学, 歯学研究科, 助教 (50530490)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 歯学 / 組織工学 / 再生歯学 / 歯髄 / 細胞集合体

Outline of Final Research Achievements

The objective of this study was to establish new technology to fabricate dental pulp-like tissue to be transplanted for regenerative medicine. The stick-shaped 3-dimensional (3D) cell construct composed of dental pulp derived stem cells were successfully fabricated by molding the sheeted cell aggregations. The cell construct prepared was found to possess the function to form dentin/pulp complex, suggesting the usefulness of our tissue engineering technology for fabrication of dental pulp-like tissue in vitro.

Free Research Field

歯科生体材料学