Differences of salivary cortisol levels in wearers of dento-maxillary prosthesis due to head and neck cancer resection

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659853
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Prosthetic dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TANIGUCHI Hisashi 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (90171850)
• Co-Investigator(Kenkyū-buntansha): SUMITA Yuka 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (10361693) ; OTOMARU Takafumi 東京医科歯科大学, 歯学部附属病院, 助教 (30549928)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 唾液 / 顎義歯 / コルチゾール / ストレス / 頭頸部癌

Outline of Final Research Achievements

Purpose: The purpose of this study was to use cortisol awakening response (CAR) to investigate the differences in daily life stress experienced by individuals wearing either along-term (LT) or a short-term (ST) dento-maxillary prosthesis following head and neck cancer (HNC) resection. Methods: Salivary samples were collected from 11 LT and 10 ST prosthesis wearers on two consecutive days at two time points, immediately after waking up (T0) and 30 min later (T30), by passive drool collection. Cortisol levels were measured and the differences between the cortisol levels at T0 and T30 (T30-T0) was compared between LT and ST prosthesis wearers. Results: A significant difference was observed in T30-T0 between the two groups. T30-T0 of the ST prosthesis wearers was significantly lower compared with that of the LT prosthesis wearers.
Conclusion: The findings suggest that individuals wearing ST dento-maxillary prostheses following HNC resection experience some sort of daily life stress.

Free Research Field

顎顔面補綴学分野