Genetic and environmental influences on oral condition and arthrosclerosis among elder twins

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659857
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Osaka University
• Principal Investigator: IKEBE KAZUNORI 大阪大学, 歯学部附属病院, 講師 (70273696)
• Co-Investigator(Kenkyū-buntansha): MAEDA Yoshinobu 大阪大学, 歯学研究科, 教授 (10144510)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 歯科補綴学一般 / 健康長寿 / 高齢者 / 双生児 / 咬合咀嚼

Research Abstract

The aim of this study was to quantify the relative contributions of genetic and environmental factors to oral disease and function in elder twins, and to estimate heritabilities. Participants were elder twins. Data were subjected to univariate genetic analysis with the structural equation modeling. In this method, variability is partitioned into variance components for additive genetic effects (A), common environmental effects (C), and individual-specific environmental effects (E). Number of teeth and periodontal disease fitted CE model. However, SSFR and masticatory performance fitted AE model. These data suggested that genetic factors contributed weakly to oral disease, but strongly to oral function. In addition, number of teeth was associated with arthrosclerosis adjusted age, gender, smoking and genetic factors.

Research Products

• [Presentation] 高齢双生児の歯周病における遺伝因子と環境因子の関与 (2013)
  • Author(s): 三木康史,山下元三,北垣次郎太,池上久仁子,久保田実木子,粟田敏仁,梶川哲宏,竹立匡秀,柳田学,野崎剛徳,山田聡,久留島悠子,松田謙一,池邉一典,北村正博,前田芳信,村上伸也
  • Organizer: 日本保存歯科学会
  • Place of Presentation: 大阪ツインリサーチグループ福岡市
  • Year and Date: 2013-06-27
• [Presentation] General Session Genetic and environmental influences on oral condition among elder twins (2013)
  • Author(s): Kurushima Y, Ikebe K, Matsuda K, Enoki K, Ogata S, Yamashita M, Murakami S, Kato K, Hayakawa K, Maeda Y
  • Organizer: 91th I.A.D.R
  • Place of Presentation: Osaka Twin Research Group Seattle, USA
  • Year and Date: 2013-03-21
• [Presentation] 高齢双生児における口腔領域の類似度 (2013)
  • Author(s): 久留島悠子,池邉一典,松田謙一,榎木香織,尾形宗士郎,山下元三,村上伸也,加藤憲司,早川和生,前田芳信
  • Organizer: 日本双生児研究学会第27回学術講演会
  • Place of Presentation: 大阪ツインリサーチグループ東京都
  • Year and Date: 2013-01-27
• [Presentation] 歯科疾患および咀嚼機能,歯列形態の遺伝要因と環境要因の影響度～高齢双生児を対象とした調査より (2013)
  • Author(s): 久留島悠子,池邉一典,松田謙一,榎木香織,尾形宗士郎,山下元三,村上伸也,加藤憲司,早川和生,前田芳信
  • Organizer: 大阪大学歯学会
  • Place of Presentation: 大阪ツインリサーチグループ吹田市
  • Year and Date: 2013-01-10