Fabrication of bone substitutes using phase transformation under supercritical reaction field

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659862
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Prosthetic dentistry
• Research Institution: Kyushu University
• Principal Investigator: TSURU Kanji 九州大学, 歯学研究科(研究院), 准教授 (50314654)
• Co-Investigator(Renkei-kenkyūsha): ISHIKAWA Kunio 九州大学, 歯学研究院・生体材料学分野, 教授 (90202952)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 生体材料 / 骨補填材 / アパタイト / 超臨界二酸化炭素

Outline of Final Research Achievements

In this study, usefulness of supercritical carbon dioxide was investigated on carbonation process of calcium hydroxide compact that was important for fabrication of carbonate apatite bone substitute. As a result, this study revealed that the existence of water was the key for carbonation of calcium hydroxide compact, and carbonation was possible when high reactive sintered calcium oxide was used. The obtained crystal phase was calcite and it could transform into carbonate apatite after hydrothermally-treated with 1 mol/l Na2HPO4 at 200 degree C for 24 hours. Moreover, in vitro cytocompatibility and in vivo osteoconductivity for the carbonate apatite obtained in this study compared favorably with the carbonate apatite fabricated using conventional method.

Free Research Field

医歯薬学