Development of a mouth moisturizer using the colloidal platinum and chymase inhibitor.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659863
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Prosthetic dentistry
• Research Institution: Nagasaki University
• Principal Investigator: MURATA Hiroshi 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (40229993)
• Co-Investigator(Kenkyū-buntansha): NISHIMURA Masahiro 鹿児島大学, 医歯学総合研究科(歯学系), 教授 (00294570) ; KUROGI Tadafumi 長崎大学, 病院(歯学系), 助教 (70404225) ; YAMASHITA Rika 長崎大学, 病院(歯学系), 助教 (50336179) ; HONG Guang 東北大学, 歯学研究科, 准教授 (80264258)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 歯学 / 保湿ジェル / ドライマウス / 白金ナノコロイド / 粘膜活性 / レオロジー / 生体親和性

Outline of Final Research Achievements

Many elderly denture patients have dry mouth and severe alveolar resorption. Thus, most of them do not wear the dentures due to decubitus ulcer and redness of denture intaglio surface. The purpose of this study is development of a mouth moisturizer using the colloidal platinum with antioxidative effect and chymase inhibitor. Rheological properties, adhesion strength and biocompatibility were mainly evaluated in the present study. Although additional evaluation of the function of mucous membrane damage healing would be necessary, rheological properties, adhesion strength and biocompatibility of mouth moisturizers were unraveled.

Free Research Field

歯科補綴学