2013 Fiscal Year Final Research Report
Experimental study towards the development of lymphatic drug delivery system for the treatment of cervical lymph node metastasis
| Project/Area Number |
24659884
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MORI SHIRO 東北大学, 大学病院, 講師 (80230069)
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| Co-Investigator(Renkei-kenkyūsha) |
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
ONO Masao 東北大学, 医学系研究科, 教授 (20302218)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 口腔癌 / ナノバブル / 超音波 / リンパ節転移 / 動物モデル / 分子導入 / 癌化学療法 / 癌治療 |
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| Research Abstract |
The present study was performed to examine the possibility of intra-lymphatic chemotherapy with minimally invasiveness for cervical lymph node metastasis by using the lymph node metastasis mouse model showing lymphadenopathy. This study revealed that selective intra-lymphatic administration of anticancer agent is available. Moreover, it became clear that irradiation of ultrasonic waves after the simultaneous administration of nano-microbubbles and anticancer agent into the metastatic lymph node via lymphatic vessel enhanced effective induction of anticancer agent into the cells of the targeted lymph node.
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[Presentation] Early diagnosis of lymph node metastasis2013
Author(s)
Hasegawa N, Kodama T, Sato T, Kochi T, Mori S
Organizer
The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
Place of Presentation
Engineering Auditorium (EA). National University of Singapore, Singapore
Year and Date
20130323-24
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