2013 Fiscal Year Final Research Report
Molecular pathogenesis of aggressive periodontitis utilizing hereditary connective tissue disorder mouse model
| Project/Area Number |
24659923
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YAMADA SATORU 大阪大学, 歯学部附属病院, 講師 (40359849)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Shinya 大阪大学, 大学院歯学研究科, 教授 (70239490)
KITAMURA Masahiro 大阪大学, 大学院歯学研究科, 准教授 (10243247)
KITAGAKI Jirouta 大阪大学, 歯学部附属病院, 特任講師 (90570292)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 遺伝性結合織疾患 / TGF-beta / 疾患モデルマウス |
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| Research Abstract |
In this study, we generated hereditary connective tissue disorder mouse model using TGF-b type I receptor point-mutation knock-in ES cells to investigate molecular pathogenesis of aggressive periodontitis. So far, knock-in hetero mice are fertile and show normal growth and development. On the other hand, knock-in homo mice is never produced. The TGF-b type I receptor point-mutation resulted in over-activation of TGF-b signal pathway in 293 cells, suggesting TGF-b signal disorder in the knock-in mice.
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