2013 Fiscal Year Final Research Report

Molecular pathogenesis of aggressive periodontitis utilizing hereditary connective tissue disorder mouse model

Research Project

Project/Area Number	24659923
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Periodontal dentistry
Research Institution	Osaka University
Principal Investigator	YAMADA SATORU 大阪大学, 歯学部附属病院, 講師 (40359849)
Co-Investigator(Kenkyū-buntansha)	MURAKAMI Shinya 大阪大学, 大学院歯学研究科, 教授 (70239490) KITAMURA Masahiro 大阪大学, 大学院歯学研究科, 准教授 (10243247) KITAGAKI Jirouta 大阪大学, 歯学部附属病院, 特任講師 (90570292)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	遺伝性結合織疾患 / TGF-beta / 疾患モデルマウス
Research Abstract	In this study, we generated hereditary connective tissue disorder mouse model using TGF-b type I receptor point-mutation knock-in ES cells to investigate molecular pathogenesis of aggressive periodontitis. So far, knock-in hetero mice are fertile and show normal growth and development. On the other hand, knock-in homo mice is never produced. The TGF-b type I receptor point-mutation resulted in over-activation of TGF-b signal pathway in 293 cells, suggesting TGF-b signal disorder in the knock-in mice.

(1 results)