2013 Fiscal Year Final Research Report

The development of high molecular substance expressing antibacterial activity derived from active oxygen

Research Project

Project/Area Number	24659930
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Social dentistry
Research Institution	Hokkaido University
Principal Investigator	MIZUNO Morimichi 北海道大学, 歯学研究科(研究院), 助教 (10125354)
Project Period (FY)	2012-04-01 – 2013-03-31
Keywords	活性酸素発生能 / 高分子化合物
Research Abstract	The purpose of the study is development of high molecular substance generating active oxygen and establishment of new oral cleaning system instead of tooth blushing. By the several investigations, the polymer composed of glucose molecule was shown to be a suitable material producing the enough amounts of active oxygen. The polymer producing active oxygen was synthesized by the mixing with 1 M of hydrogen peroxide solution, followed by the removal of water and grinding to make a powder (solid active oxygen powder). The solid active oxygen powder was most stable when their particle size was between 100 and 200 micro-meter. Furthermore, Maillard reaction product (MRP) synthesized from monosaccharide and amino acid promoted the stability of active oxygen exist in solid active oxygen powder. Especially, MRP synthesized from glucose and histidine was most effective to stabilize the active oxygen among investigated MRPs.