New theory for pain control in the maxillofacial regions by sialorphin, saliva-derived antinociceptive modulator.

2015 Fiscal Year Final Research Report

• Project/Area Number: 24659932
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: Shoji Noriaki 東北大学, 大学病院, 講師 (70250800)
• Co-Investigator(Kenkyū-buntansha): SASANO TAKASHI 東北大学, 歯学研究科(研究院), 教授 (10125560) ; SUGIMOTO KOREAKI 東北福祉大学, 総合福祉学部, 教授 (30361158) ; SASANO TAKASHI 東北大学, 歯学研究科(研究院), 助教 (80447169)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: シアロルフィン / 急性痛 / 慢性痛

Outline of Final Research Achievements

Recently, patients with atypical tooth pain, glossodynia and tempolomandibular disorder have been increasing and this phenomenon was recognized as social issues. This study was designed to determine whether sialorphin that displays analgesic activity can be effective for pain control in the maxillofacial regions both of the acute-pain model rats induced by formalin injection and of the chronic-pain ones induced by trigeminal (maxillary) nerve constriction. In conclusion, sialorphin had inhibitory effect both on the formalin-induced acute pain and on the chronic pain induced by nerve constriction.

Free Research Field

口腔内科学