2014 Fiscal Year Final Research Report
Development of in vitro models of extracellular environments and thier applications to cell function study
| Project/Area Number |
24680050
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Saitama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 細胞接着 / 細胞力学 / 光計測 / 高分子基板 / がん細胞 / 細胞組織形成 / ソフトマター / 脂質膜 |
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| Outline of Final Research Achievements |
New experimental platforms for the quantitative evaluation of the influence of extracellular environments on cell functions have been developed. This platform utilizes hydrogel or lipid membrane substrate with tunable mechanical and biochemical cues. It was successfully demonstrated that various cell responses (e.g., adhesion strength and local cell membrane structure) to the substrate as in vitro models of extracellular environments could be evaluated by using our original optical methods. Finally, the systematic measurements by using the experimental platform could provide quantitative insights into the cell-environment mechanical interactions that promote cancer metastasis and tissue formation.
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| Free Research Field |
生物物理化学
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