2015 Fiscal Year Final Research Report
Biomechanical analysis of the nuclear-cytoskeletal interactions to elucidate the cellular mechanotransduction mechanism
| Project/Area Number |
24680051
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Ibaraki University (2014-2015)
Nagoya Institute of Technology (2012-2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 細胞バイオメカニクス / メカノバイオロジー / 細胞骨格 / 細胞核 / DNA / メカノトランスダクション / 生体計測 |
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| Outline of Final Research Achievements |
The purpose of this study is to investigate the roles of the nuclear-cytoskeletal interactions in vascular smooth muscle differentiation. We found that mechanical interaction between actin cytoskeleton and the nucleus significantly increased and chromatin condensation could be observed clearly during smooth muscle differentiation. The cell tissue orientation and cyclic stretch mechanical stimulation also induced the nuclear-cytoskeletal interactions and induced the smooth muscle differentiation. The results of this study will provide new prospects of cellular mechanotransduction mechanism.
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| Free Research Field |
細胞バイオメカニクス，メカノバイオロジー
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