2014 Fiscal Year Final Research Report
Elucidation of the regulatory mechanism of fatty acid composition in the cell and its role in brain function and mental disease
| Project/Area Number |
24680072
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 脂肪酸 / 脳 |
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| Outline of Final Research Achievements |
We analyzed the role of fatty acid elongase Elovl6 in brain by using Elovl6 deficient mice and brain-specific Elovl6 deficient mice. Elovl6 deficiency in brain caused decreased the relative content of stearate (C18:0) and increased the relative content of palmitate (C16:0) compared to control. The weight of the brain was significantly heavier in Elovl6 deficient mice than in wild- type mice. Mutant hippocampus exhibited decreased neural precursors and spine density. Memory impairment, enhanced anxiety and decreased motivation were observed in Elovl6 deficient mice. Moreover, Elovl6 deficiency increased proliferation and differentiation of astrocyte and neuron in primary hippocampal culture cells. Thus, Elovl6 is crucial for the development and function of the central nervous system.
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| Free Research Field |
代謝内分泌学
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