2015 Fiscal Year Final Research Report
Comprehensive analysis of pro-inflammatory metabolites in feces for the development of diagnostic biomarkers of metabolic syndrome
| Project/Area Number |
24680075
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 生活習慣病 / 炎症 |
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| Outline of Final Research Achievements |
It is strongly suggested that intestinal microflora is playing pivotal roles in metabolic homeostasis. However some factors, stress, aging, and dietary pattern, possibly influence the intestinal microflora, in which deteriorated composition possibly triggers the low-grade chronic inflammation associated with several lifestyle-related diseases including obesity and diabetic mellitus. In this study, we explored pro-inflammatory molecules in feces from metabolic syndrome model animals. We identified precursor or metabolites of heme were prominently increased in feces of disease group animals including ob/ob, KK-Ay, high-fat fed C57BL/6J mice, and also found that oral administration of the heme metabolites for 8weeks in normal C57BL/6J mice impaired the glucose metabolism. These results suggest that pro-inflammatory metabolites formed in small intestine could be affect to the metabolism of dietary nutrition in host.
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| Free Research Field |
食品機能学
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