2013 Fiscal Year Final Research Report
Stimuli-responsive nano-shells for caging living cells
| Project/Area Number |
24686094
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 細胞工学 / 光応答性材料 / 細胞パターニング / 細胞接着 / 自己集合 |
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| Research Abstract |
We developed methods for preparing "caged cells", which are covered with the nano-shell consisting of stimuli-responsive polymer complexes to control the cellular functions with external stimuli. In this study, light stimulation was selected as the external stimulus because of its high spatio-temporal resolution, and photo-cleavable nano-shells were challenged to be developed. For the cell-coating material, a photo-degradable hydrogel was produced by self-assembly of biocompatible polymers through a photo-cleavable linker group. Then, the method for coating cellular surfaces with the present photo-degradable self-assembly materials was optimized for tightly caging living cells, and the functions of caged cells such as elongation, adhesion and phagocytosis were successfully confirmed to be controlled by light irradiation.
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Research Products
(31 results)
