2014 Fiscal Year Final Research Report
Molecular mechanism for opposite synaptic transmission in neural circuit of C. elegans
| Project/Area Number |
24687002
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Konan University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 線虫 / C. elegans / 温度応答 / 神経回路 / カルシウムイメージング |
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| Outline of Final Research Achievements |
To identify molecular and physiological mechanisms for complicated-synaptic transmission system and compartment of synapse localization, we used simple neural circuit underlying temperature sensation and response. We utilized molecular genetics and optical imaging of various mutants of nematode C. elegans. We found that molecular mechanism for self-activation of glutamate signaling, compartmentalization between pre- and post synapses in single neural process, and novel paradigm for analysis of temperature response.
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| Free Research Field |
分子神経遺伝学
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