Structural basis for the mechanism of endocytosis involved in oncogenic transformation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24687014
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Structural biochemistry
• Research Institution: Kyushu University
• Principal Investigator: SHIMADA Atsushi 九州大学, 生体防御医学研究所, 准教授 (70391977)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: X線結晶構造解析 / エンドサイトーシス / がん

Outline of Final Research Achievements

Endocytosis is a process for eukaryotic cells to internalize extracellular molecules into the cells, which plays an important role in various physiological processes, such as receptor internalization. Endocytosis is also recently implicated in oncogenic transformation. In this study, we performed the structural and functional analyses of endocytic proteins involved in oncogenic transformation. We revealed the mechanism of the recognition of Eps15, which is deeply involved in oncogenic transformation, by SGIP1 and FCHo1, which are key players of the clathrin-assembly step of clathrin-mediated endocytosis. Thus, this study deepens our understanding of the link between oncogenic transformation and endocytosis.

Free Research Field

構造生物学、生化学