Structural, functional, and pathological studies on a novel "post-phosphoryl sugar chain"

2014 Fiscal Year Final Research Report

• Project/Area Number: 24687017
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Functional biochemistry
• Research Institution: Kobe University
• Principal Investigator: KANAGAWA Motoi 神戸大学, 医学(系)研究科(研究院), 講師 (00448044)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 糖鎖 / 筋ジストロフィー / ジストログリカン / 遺伝子治療

Outline of Final Research Achievements

This study aimed at understanding of structure, modification mechanism, and physiological roles of novel post-translational modification termed “post-phosphoryl sugar chain”. We also examined the pathogenesis of diseases caused by defects in post-phosphoryl modification in order to develop therapeutic strategies. Structural analysis on unique recombinant glycoprotein and functional analysis of the disease gene products opened a new roadmap toward full understanding of the molecular basis of post-phosphoryl modification. Analysis on disease mouse models revealed a new pathogenesis of muscular dystrophy, which led us to propose an effective therapeutic strategy for muscular dystrophy.

Free Research Field

機能生物化学