Establishment and characterization of a new mouse model for allergic disorders

2014 Fiscal Year Final Research Report

• Project/Area Number: 24688029
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: The University of Tokyo
• Principal Investigator: NAKAE Susumu 東京大学, 医科学研究所, 准教授 (60450409)
• Research Collaborator: NAMBU Aya 東京大学, 医科学研究所, 特任研究員 (10456197) ; MATSUMOTO Kenji 独立行政法人国立成育医療センター研究所, 免疫アレルギー研究部, 部長 (60181765) ; SUDO Katsuko 東京医科大学, 医学部, 講師 (50126091)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 応用動物学 / 免疫学 / アレルギー

Outline of Final Research Achievements

NC/Nga mice, which develop a spontaneous skin inflammation resembling atopic dermatitis in human under the conventional condition, are well used as one of a mouse model for human atopic dermatitis. Since these mice do not develop the disease under the SPF condition, it is difficult to elucidate the molecular mechanism of atopic dermatitis using these mice in the setting. Therefore, we newly established a mouse model for human atopic dermatitis in the SPF condition; we found that mice developed skin inflammation resembling human atopic dermatitis by epicutaneous application with a protease antigen. We are studying the detail molecular mechanism of development of the protease-induced dermatitis.

Free Research Field

農学