2014 Fiscal Year Final Research Report
Analysis of intracellular traffic of siRNA
| Project/Area Number |
24689005
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
INOUE Takao 国立医薬品食品衛生研究所, 遺伝子医薬部, 室長 (50361605)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 核酸医薬 / RNAi / siRNA |
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| Outline of Final Research Achievements |
Oligonucleotide therapeutics, such as siRNA and antisense oligonucleotides, has attracted attention as an innovative medicine for intractable diseases that have no cure. However, it is largely unknown how oligonucleotide therapeutics is incorporated into the cell, and subsequently, transported to the target RNA. In this study, we identified some molecules which are involved in incorporation of oligonucleotides into HEK293 cells.
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| Free Research Field |
生化学
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