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2014 Fiscal Year Final Research Report

Discovery of drug candidates by using in situ click chemistry

Research Project

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Project/Area Number 24689007
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Drug development chemistry
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

SUZUKI Takayoshi  京都府立医科大学, 医学(系)研究科(研究院), 教授 (90372838)

Project Period (FY) 2012-04-01 – 2015-03-31
Keywordsヒストン脱アセチル化酵素 / アイソフォーム / クリックケミストリー / アジド / アルキン / トリアゾール / 阻害薬
Outline of Final Research Achievements

In drug discovery, high-throughput screening, structure-based drug design, and ligand-based drug design are generally used. However, these methods take great time and effort.
With the background like this, we tried to identify selective inhibitors using click chemistry. As a result, we rapidly identified promising inhibitors by this method, suggesting the usefulness of this method in drug discovery.

Free Research Field

創薬化学

URL: 

Published: 2016-06-03  

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