Discovery of drug candidates by using in situ click chemistry

2014 Fiscal Year Final Research Report

• Project/Area Number: 24689007
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Drug development chemistry
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: SUZUKI Takayoshi 京都府立医科大学, 医学(系)研究科(研究院), 教授 (90372838)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ヒストン脱アセチル化酵素 / アイソフォーム / クリックケミストリー / アジド / アルキン / トリアゾール / 阻害薬

Outline of Final Research Achievements

In drug discovery, high-throughput screening, structure-based drug design, and ligand-based drug design are generally used. However, these methods take great time and effort.
With the background like this, we tried to identify selective inhibitors using click chemistry. As a result, we rapidly identified promising inhibitors by this method, suggesting the usefulness of this method in drug discovery.

Free Research Field

創薬化学