2014 Fiscal Year Final Research Report
Establishment of a screening system for therapeutically effective antibiotics
| Project/Area Number |
24689008
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Environmental pharmacy
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 感染症 / 微生物 / 抗生物質 / カイコ / 次世代シークセンサー |
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| Outline of Final Research Achievements |
Primary mechanistic analysis of lysocin E, identified using a silkworm infection model was performed. In addition, the serum factors that enhances antimicrobial activity of lysocin E were purified and identified. Moreover, serum from various animals including human and silkworm hemolymph also enhanced antimicrobial activity of lysocin E. Further, a method was established to analyze comprehensive gene expression of bacteria during infection in mouse organs. Disruption of genes, whose functions are not known, showed reduced pathogenicity in mouse systemic infection model. These results suggested that a principle of a screening system for therapeutically effective antibiotics was established.
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| Free Research Field |
微生物学
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