2014 Fiscal Year Final Research Report
Functional analysis of transcription elongation regulatory factor Med26
| Project/Area Number |
24689016
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 生化学 / 転写 / RNAポリメラーゼII / 転写伸長 |
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| Outline of Final Research Achievements |
Regulation of transcription elongation by RNA polymerase II (Pol II) is a key regulatory step in gene transcription. We showed that the human Mediator subunit MED26 plays a role in the recruitment of transcription elongation complexes, SEC and LEC to the different types of genes.
It has been reported that the expression of many genes is strictly controlled and that the dysregulation of the gene expression often causes cancers or leukemias. Since MED26 also regulates the expression of cancer-related genes, it is possible that MED26 is one of the important molecules to regulate carcinogenesis and leukemogenesis.
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| Free Research Field |
生化学
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