2015 Fiscal Year Final Research Report
The role of novel metabolite, O-acetyl-ADP-Ribose
| Project/Area Number |
24689019
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | University of Toyama |
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Principal Investigator |
NAKAGAWA TAKASHI 富山大学, 先端ライフサイエンス拠点, 特命助教 (40610374)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 代謝 / メタボローム / NAD |
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| Outline of Final Research Achievements |
In this study, I investigated the physiological role of novel metabolite, O-acetyl-ADP-Ribose (OAADPR). First, the system to measure the OAADPR was established by using LC/MS. Next, I focused on the enzyme, Nudt5, which catabolized the OAADPR. I generated the Nudt5- knocked down cell and examined the intracellular metabolism in these cells, and found that various NAD-related metabolites were altered in these cells.
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| Free Research Field |
代謝学
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