Mechanisms for selective endocytosis and its involvement in the pathogenesis of cancer and psychiatric disorders

2014 Fiscal Year Final Research Report

• Project/Area Number: 24689021
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Nagoya University
• Principal Investigator: ENOMOTO Atsushi 名古屋大学, 医学(系)研究科(研究院), 准教授 (20432255)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: Girdin / 細胞運動 / エンドサイトーシス

Outline of Final Research Achievements

Despite the importance of the endocytosis of receptors and cell adhesion proteins, which is essential for various cellular processes, the mechanisms for the specificity and spatial control of the endocytosis have remained unknown. We previously identified the actin-binding protein Girdin that regulates the migration of neuroblasts in the postnatal brain and cancer cells. In the present study, we revealed that Girdin interacts with dynamin, which is central to the scission of membrane vesicles and subsequent endocytosis, to regulate the specificity of endocytosis. By using genetically engineered mice and cultured cells, we also demonstrated that the endocytosis mediated by the Girdin/dynamin complex has a role in the migration of neuroblasts and is involved in aberrant polarization of cancer cells.

Free Research Field

実験病理学