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2014 Fiscal Year Final Research Report

Elucidation of the molecular mechanism of ABC transporters

Research Project

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Project/Area Number 24689029
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Applied pharmacology
Research InstitutionKyoto University

Principal Investigator

KODAN Atsushi  京都大学, 物質ー細胞統合システム拠点, 助教 (80360543)

Project Period (FY) 2012-04-01 – 2015-03-31
Keywords生体分子 / 膜タンパク質 / 癌 / 多剤耐性 / 立体構造解析 / X線結晶構造解析 / ABCタンパク質 / P糖タンパク質
Outline of Final Research Achievements

In this study, the highest-resolution crystal structures of a eukaryotic P-glycoprotein homolog from the red algae Cyanidioschyzon merolae, were determined in two forms: unbound at 2.6-angstrom resolution and bound to a unique allosteric inhibitor at 2.4-angstrom resolution. These structures, along with site-directed mutagenesis and transporter activity measurements, reveal the detailed architecture of the transporter, including a gate that opens to extracellular side and two gates that open to intramembranous region and the cytosolic side.

Free Research Field

構造生物学、生化学

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Published: 2016-06-03  

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