"Combination-oriented molecular-targeting prevention" of cancer via the activation of TRAIL pathway by targeting microRNA.

2015 Fiscal Year Final Research Report

• Project/Area Number: 24689031
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Hygiene
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Tomosugi(Horinaka) Mano (堀中真野) 京都府立医科大学, 医学(系)研究科(研究院), 講師 (80512037)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: がん / microRNA / TRAIL / 予防

Outline of Final Research Achievements

TRAIL is a cytokine which can induce apoptosis against cancer cells, and contribute to cancer prevention. We considered possibility of the involvement of microRNA as one of the mechanisms of regulation of TRAIL expression. As the results of examinations for several candidate microRNAs including miR-145, we found that certain microRNA (miR-X) significantly induced the expression of TRAIL in human cancer cells. The activity of TRAIL promoter was up-regulated by the microRNA, miR-X. Furthermore, this study showed that miR-X was partially involved in the mechanism of TRAIL induction by the metabolism product derived from a dietary fiber reported as TRAIL inducer.

Free Research Field

がん予防