Investigating the role of sugar chain in microenvironment of skin cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24689045
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Dermatology
• Research Institution: Osaka University
• Principal Investigator: TERAO mika 大阪大学, 医学(系)研究科(研究院), 特任研究員 (40570669)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 糖転移酵素 / GnT-V / M1マクロファージ / M2マクロファージ / 皮膚がん / 悪性黒色腫 / 皮膚硬化 / 強皮症

Outline of Final Research Achievements

N-Acetylglucosaminyltransferase-V (GnT-V) expression is elevated during malignant transformation in various types of cancer. To characterize the biological function of GnT-V in macrophages,we analyzed the role of GnT-V using GnT-V knockout (KO) mice. In bone marrow-derived macrophages (BMDMs), IL-4-induced expressions of M2 macrophage markers were reduced in KO mice. In addition, KO mice were resistant to BLM-induced skin sclerosis with reduced number of CD163+ M2 macrophages. These results suggest the importance of GnT-V in differentiation of M2 macrophages in the skin.

Free Research Field

医歯薬学