Development of novel kind of radioprotectors that relieve the damage of normal tissues in radiation injury

2015 Fiscal Year Final Research Report

• Project/Area Number: 24689050
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Radiation science
• Research Institution: The University of Tokushima (2013-2015); Hiroshima University (2012)
• Principal Investigator: MORITA Akinori 徳島大学, 大学院医歯薬学研究部, 教授 (90334234)
• Research Collaborator: AOKI Shin 東京理科大学, 薬学部, 教授 (00222472) ; WANG Bing 放射線医学総合研究所, 放射線防護研究センター, チームリーダー (10300914)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 放射線防護剤 / p53制御剤 / p53阻害剤 / アポトーシス

Outline of Final Research Achievements

Research for developing radioprotectors is extremely important as one of a few methods to reduce a radiation risk. In addition, the damage of normal tissues during radiation therapy produces a dose-limiting toxicity (tolerance dose). Therefore, the development of the radioprotectors that raise the tolerance dose is expected. As radioprotective usefulness by regulating p53, some chemical p53 regulators would be expected to selectively prevent the damage of normal tissues during radiotherapy for p53-deficient tumors. In this study, I attempted to discover compounds that target the zinc-binding site in p53, and found several radioprotectors that regulate p53.

Free Research Field

放射線生物学