2014 Fiscal Year Final Research Report
Generation of vascularized and functional tissues from human iPS cell
| Project/Area Number |
24689052
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 再生医学 |
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| Outline of Final Research Achievements |
Critical shortage of donor organs for treating end-stage organ failure highlights the urgent need for generating organs from induced pluripotent stem cells (hiPSCs). Despite many reports describing functional cell differentiation, no studies have succeeded in generating a three-dimensional vascularised organ such as liver. In this program, we showed the generation of vascularised and functional human liver from hiPSCs by transplantation of liver buds created in vitro (hiPSC-LBs). Mesenteric transplantation of hiPSC-LBs rescued the drug-induced lethal liver failure model. Furthermore, similar principle was extended to generate vascularized pancreatic islet towards therapy. Although efforts must ensue to translate these techniques to patients, our proof-of-concept, i.e. organ bud transplantation, provides a promising new approach towards regenerative medicine.
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| Free Research Field |
再生医学
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