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2014 Fiscal Year Final Research Report

Generation of vascularized and functional tissues from human iPS cell

Research Project

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Project/Area Number 24689052
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field General surgery
Research InstitutionYokohama City University

Principal Investigator

TAKEBE TAKANORI  横浜市立大学, 医学部, 准教授 (20612625)

Project Period (FY) 2012-04-01 – 2015-03-31
Keywords再生医学
Outline of Final Research Achievements

Critical shortage of donor organs for treating end-stage organ failure highlights the urgent need for generating organs from induced pluripotent stem cells (hiPSCs). Despite many reports describing functional cell differentiation, no studies have succeeded in generating a three-dimensional vascularised organ such as liver. In this program, we showed the generation of vascularised and functional human liver from hiPSCs by transplantation of liver buds created in vitro (hiPSC-LBs). Mesenteric transplantation of hiPSC-LBs rescued the drug-induced lethal liver failure model. Furthermore, similar principle was extended to generate vascularized pancreatic islet towards therapy. Although efforts must ensue to translate these techniques to patients, our proof-of-concept, i.e. organ bud transplantation, provides a promising new approach towards regenerative medicine.

Free Research Field

再生医学

URL: 

Published: 2016-06-03  

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