Perioperative glycemic variability in patients with diabetics melitus

2014 Fiscal Year Final Research Report

• Project/Area Number: 24689059
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kobe University (2013-2014); National Cancer Center Japan (2012)
• Principal Investigator: EGI Moritoki 神戸大学, 医学部附属病院, 講師 (20423296)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 糖尿病 / 手術 / 集中治療 / 血糖値 / 変動

Outline of Final Research Achievements

We included 107 patients required major operation with the presence of diabetes mellitus. The preoperative HbA1c level in this cohort was 7.5±１.5% in average. The perioperative glycemic gap, which is calculated as the difference between the estimated average of preoperative blood glucose levels and time weighted average of postoperative glycemia, was median of -5 (interquartile range -42, 21)mg/dL. There is significant association with the perioperative glycemic gap with the urine 8-iso-ProstaglandinF2α, which is a surrogate of oxidative stress (p=0.002).

Free Research Field

麻酔・集中治療