State-space remodeling in basal ganglia

2013 Fiscal Year Final Research Report

• Project/Area Number: 24700200
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Perception information processing/Intelligent robotics
• Research Institution: National Defense Medical College
• Principal Investigator: OHTA Hiroyuki 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 助教 (20535190)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 強化学習 / 大脳基底核 / 線条体

Outline of Final Research Achievements

The striatum neurons showed a residual firing response of slowly increasing duration when exposed to repetitive optogenetic photostimulation. The prolonged firing resumed after a 20 sec intermission. Residual depolarization with 8-sec half-life decay and firing prolongation by the repetitive photostimulation were observed through whole-cell patch clamp recordings. Our results indicate that striatal neurons hold their internal state in second-order timescale to count inputs cumulatively. Moreover, we proposed a new reinforcement learning model which was inspired by the prolonged firing.

Free Research Field

総合領域