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2013 Fiscal Year Final Research Report

The Closest-Neighbor Trimming Algorithm for Resampling Genetic Sequence Datasets

Research Project

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Project/Area Number 24700289
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bioinformatics/Life informatics
Research InstitutionNagahama Institute of Bio-Science and Technology

Principal Investigator

YONEZAWA Kouki  長浜バイオ大学, バイオサイエンス学部, 助手 (00374744)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywordsバイオインフォマティクス / 人獣共通感染症 / リサンプリング / 分子系統樹
Research Abstract

A large number of nucleotide sequences of various pathogens are available in public databases. The growth of the datasets has resulted in an enormous increase in computational costs. Moreover, due to differences in surveillance activities, the number of sequences found in databases varies from one country to another and from year to year. Therefore it is important to study resampling methods to reduce the sampling bias. A novel algorithm| called the closest-neighbor trimming method|that resamples a given number of sequences from a large nucleotide sequence dataset was proposed. The performance of the proposed algorithm was compared with other algorithms by using the nucleotide sequences of human H3N2 influenza viruses. Since nucleotide sequences are among the most widely used materials for life sciences, we anticipate that our algorithm to various datasets will result in reducing sampling bias.

  • Research Products

    (10 results)

All 2013 2012 Other

All Journal Article (2 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Resampling nucleotide sequences with closest-neighbor trimming and its comparison to other methods2013

    • Author(s)
      Kouki Yonezawa, Manabu Igarashi, Keisuke Ueno, Ayato Takada, Kimihito Ito
    • Journal Title

      PLoS One

      Volume: 8(2) Pages: e57684

    • DOI

      10.1371/journal.pone.0057684

  • [Journal Article] A Trim Distance between Positions as Packaging Signals in H3N2 Influenza Viruses2012

    • Author(s)
      Shunsuke Makino, Takaharu Shimada, Kouichi Hirata, Kouki Yonezawa, Kimihito Ito
    • Journal Title

      The 6th International Conference on Soft Computing and Intelligent Systems and the 13th International Symposium on Advanced Intelligent Systems

  • [Presentation] Resampling of Large Nucleotide Sequence Datasets of Viruses with Closest-Neighbor Trimming Method2013

    • Author(s)
      Kouki Yonezawa, Manabu Igarashi, Kimihito Ito
    • Organizer
      Annual Meeting of Society for Molecular Biology & Evolution (SMBE 2013)
    • Year and Date
      20130707-11
  • [Presentation] 近隣剪定法によるウイルス遺伝子配列のリサンプリング2013

    • Author(s)
      米澤弘毅,五十嵐学,伊藤公人
    • Organizer
      第7回ゲノム微生物学会年会
    • Place of Presentation
      長浜バイオ大学
    • Year and Date
      20130308-10
  • [Presentation] 近隣剪定法によるウイルス遺伝子配列のリサンプリング2013

    • Author(s)
      米澤弘毅,五十嵐学,伊藤公人
    • Organizer
      感染症若手フォーラム2013
    • Place of Presentation
      北広島クラッセホテル
    • Year and Date
      20130228-0302
  • [Presentation] Clustering of Positions in Nucleotide Sequences by Trim Distance2013

    • Author(s)
      Takaharu Shimada, Shunsuke Makino, Kouichi Hirata, Kouki Yonezawa, Kimihito Ito
    • Organizer
      CSBB 2013
    • Place of Presentation
      のがみプレジデントホテル
    • Year and Date
      20130228-0301
  • [Presentation] 近隣結合法による塩基配列データセットのリサンプリングとその性能評価2013

    • Author(s)
      米澤弘毅,五十嵐学,伊藤公人
    • Organizer
      第88回人工知能基本問題研究会
    • Place of Presentation
      石垣市民会館
    • Year and Date
      20130124-25
  • [Presentation] 近隣剪定法 : 進化系統樹を利用した配列リサンプリングアルゴリズム2012

    • Author(s)
      米澤弘毅,五十嵐学,伊藤公人
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      20121113-15
  • [Presentation] 近隣剪定法 : 進化系統樹を利用した配列リサンプリングアルゴリズム2012

    • Author(s)
      米澤弘毅,五十嵐学,伊藤公人
    • Organizer
      第29回バイオ情報学研究会
    • Place of Presentation
      沖縄科学技術大学院大学
    • Year and Date
      20120628-29
  • [Remarks] Biological Sequence Resampling

    • URL

      http://citrus.nagahama-i-bio.ac.jp/resampling/

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Published: 2015-06-25  

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