2013 Fiscal Year Final Research Report
Establishment of multidrug-resistant bacteria using laboratory automation and analysis of their evolution processes
| Project/Area Number |
24700305
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
SUZUKI Shingo 独立行政法人理化学研究所, 生命システム研究センター, 研究員 (60379154)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 薬剤耐性 / 多剤耐性 / 実験進化 / 大腸菌 / 進化プロセス / トレードオフ / 交差耐性 / 超感受性 |
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| Research Abstract |
Emergence and spread of bacteria exhibiting resistance to multidrug have become serious problems. Analysis of evolution process of multidrug-resistance using experimental evolution revealed that multidrug-resistant bacteria showed cross-resistance and hypersensitivity to other classes of antibiotics. In this study, whole-genome resequencing of resistant bacteria revealed the molecular mechanism underlying hypersensitivity and combination of two antibiotics showing hypersensitivity to each other could prevent the development of antibiotic resistance.
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