2015 Fiscal Year Final Research Report
Genetic and cellular mechanisms generating sexually dimorphic neuronal structures and behavior in Drosophila
Project/Area Number |
24700309
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Neuroscience in general
|
Research Institution | Tohoku University |
Principal Investigator |
Sato Kosei 東北大学, 生命科学研究科, 助教 (40451611)
|
Project Period (FY) |
2012-04-01 – 2016-03-31
|
Keywords | ショウジョウバエ / 性行動 / 脳 / 性差 / fruitless / RNAスプライシング / ユビキチン / BTB/POZ |
Outline of Final Research Achievements |
The Drosophila gene fruitless produces male-specific Fruitless, which orchestrates the expression of ~100 target genes, although their transcription is not always sex-specific. This study shows that Fruitless produces sex differences in a target gene product Lola by blocking its proteolysis; males with Fruitless acquire full-length Lola whereas females acquire a Lola proteolytic product, and both Lola products induce distinct sex-specific neural characteristics. Fruitless transcribes lola, protects Lola from proteolysis and forms a complex with Lola for transcriptional regulation. This triad of interactions control neuronal sexual differentiation underlying gendered behavior in Drosophila.
|
Free Research Field |
神経遺伝学
|