2013 Fiscal Year Final Research Report
The role of lateral inhibition in compensation of sensory function
| Project/Area Number |
24700330
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 側方抑制 / バレル皮質 / シナプス可塑性 |
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| Research Abstract |
Loss of one type of sensory input can cause improved functionality of other sensory systems. This form of plasticity, cross-modal plasticity, is well established . We have previously shown that visual deprivation (VD) induces trafficking of the AMPA-type glutamate receptors into layer 4 to layer 2/3 synapses (Jitsuki et al., 2011). VD leads to sharpening of the functional whisker-barrel map at layer 2/3. However, the mechanism maintaining sharpened functional whisker barrel map is still unclear.In this study, we found that VD increases evoked miniature inhibitory postsynaptic current (evoked mIPSC) and IPSC/excitatory postsynaptic current (EPSC) ratio in the layer 2/3 to 2/3 synapses (lateral pathway), but not in the layer 4 to 2/3 (vertical pathway). Moreover, VD sharpened functional whisker-barrel map in layer 2/3 of the barrel cortex. These results indicate that VD enhances lateral inhibition and that maintains sharpened neural circuits in the barrel cortex.
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[Journal Article] Social isolation perturbs experience-driven synaptic glutamate receptor subunit 4 delivery in the developing rat barrel cortex2013
Author(s)
Miyazaki, T., Kunii, M., Jitsuki, S., Sano, A., Kuroiwa, Y., Takahashi, T.
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Journal Title
Eur J Neurosci
Volume: 37
Pages: 1602-1609
DOI
Peer Reviewed
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