2013 Fiscal Year Final Research Report
Elucidation of the effect of PIP2 on the synaptic plasticity
| Project/Area Number |
24700348
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | Kanazawa Medical University (2013)
The Institute of Physical and Chemical Research (2012) |
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Principal Investigator |
UEDA Yoshibumi 金沢医科大学, 医学部, 特定助教 (60391877)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 神経科学 / 脳神経 / 脂質 / FRET / 蛍光寿命 / シナプス可塑性 |
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| Research Abstract |
Synapses change its morphology and size in response to outputs out of a brain, and therefore provide flexibility to neuronal network in brain. Phosphatidylinositol 3,4,5-trisphoshate (PIP3) plays important roles in neuronal functions such as dendritic arborization and synapse plasticity. It has been unknown how PIP3 work for synapses. In the present study, I found that PIP3 regulates spinule formation in a single dendritic spine during long-term potentiation.
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