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2013 Fiscal Year Final Research Report

Genetic identification of the habenular pathway regulating the monoamines metabolism in the brain

Research Project

  • PDF
Project/Area Number 24700350
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nerve anatomy/Neuropathology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

AIZAWA Hidenori  東京医科歯科大学, 難治疾患研究所, 准教授 (80391837)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords手綱核 / モノアミン
Research Abstract

Habenular subnuclei in the rodents were characterized by the heterogeneity of the neurons in expression of marker genes for glutamatergic, cholinergic and substance P-ergic transmission and monoaminergic receptors. Tamoxifen injection to Dbx1CreERT2/+ knock-in mouse line before (embryonic days 12-16) and after birth (postnatal days 0-3) resulted in the ubiquitous labeling of the cells in the adult forebrain and specific labeling of the astrocytes in the adult habenula, respectively. Electrophysiological study revealed that the habenula lesion elicited the impairment of the hippocampal theta oscillation, which was dependent upon the intact serotonergic raphe in the brain stem. These results suggested that the habenula affected the diverse brain activity via modulation of neuronal activity in the monoaminergic neurons.

  • Research Products

    (10 results)

All 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Hyperactivation of the habenula as a link between depression and sleep disturbance2013

    • Author(s)
      Aizawa H, Cui W, Tanaka K, Okamoto H.
    • Journal Title

      Front Hum Neurosci

      Volume: 7 Pages: 826

    • DOI

      10.3389/fnhum.2013.00826

    • Peer Reviewed
  • [Journal Article] The synchronous activity of lateral habenular neurons is essential for regulating hippocampal theta oscillation2013

    • Author(s)
      Aizawa H, Yanagihara S, Kobayashi M, Niisato K, Takekawa T, Harukuni R, McHugh TJ, Fukai T, Isomura Y, Okamoto H.
    • Journal Title

      J Neurosci

      Volume: 33(20) Pages: 8909-21

    • DOI

      10.1523/JNEUROSCI.4369-12.2013

    • Peer Reviewed
  • [Journal Article] Habenula and the asymmetric development of the vertebrate brain2013

    • Author(s)
      Aizawa H.
    • Journal Title

      Anat Sci Int

      Volume: 88(1) Pages: 1-9

    • DOI

      10.1007/s12565-012-0158-6

    • Peer Reviewed
  • [Journal Article] Molecular characterization of the subnuclei in rat habenula2012

    • Author(s)
      Aizawa H, Kobayashi M, Tanaka S, Fukai T, Okamoto H.
    • Journal Title

      J Comp Neurol

      Volume: 520 Pages: 4051-4066

    • DOI

      10.1002/cne.23167

    • Peer Reviewed
  • [Presentation] Activation of the lateral habenula under the acute and chronic stress2013

    • Author(s)
      崖万鵬,田中光一,相津秀紀
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Year and Date
      2013-06-21
  • [Presentation] Role of the lateral habenula in pathophysiology of major depression2013

    • Author(s)
      相津秀紀
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Year and Date
      2013-06-20
  • [Presentation] うつ病様行動における手綱核の役割2013

    • Author(s)
      崖万鵬,孫偉楠,田中光一,相津秀紀
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川
    • Year and Date
      2013-03-30
  • [Presentation] Activation of habenula neurons in the social avoidance behavior after chronic social stress2012

    • Author(s)
      崖万鵬,田中光一,相津秀紀
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
  • [Presentation] Temporally-regulated neurogenesis and gliogenesis in the mouse habenula2012

    • Author(s)
      相津秀紀,崖万鵬,田中光一
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-19
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/aud/index.html

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Published: 2015-06-25  

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