2013 Fiscal Year Final Research Report
p73 signaling regulates mice depressive behavior thorough control of adult neurogenesis.
| Project/Area Number |
24700355
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | p73 / 神経幹細胞 |
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| Research Abstract |
In order to establish animal model of depression, low dose glucocorticoid was administered to wild type mice as previous report, but it failed. Then we established p73 knock-in and knockout mouse, and confirmed p73 has no expression in adult hippocampus. Even with restraint, p73 expression is not changed in hippocampus. However we have finally found that p73 regulates ependymal cell cycle. Brain injury induces TAp73 expression and it decreases ependymal cell proliferation via unknown humoral signaling.
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[Journal Article] Transient maternal IL- 6 mediates long- lasting changes in neural stem cell pools by deregulating an endogenous self- renewal pathway2013
Author(s)
Gallagher D, Norman AA, Woodard CL, Yang G, Gauthier- Fisher A, Fujitani M, Vessey JP,Cancino GI, Sachewski N, Woltjen K, Fatt MP, Morshead CM,Kaplan DR, Miller FD.
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Journal Title
Cell stem cell 2013
Volume: 13(5)
Pages: 564-576
Peer Reviewed
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