Study for the experience-dependent reorganization of neural circuits.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700362
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: TARUSAWA Etsuko 生理学研究所, 行動・代謝分子解析センター, 特別協力研究員 (00446262)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 神経回路

Outline of Final Research Achievements

To reveal the mechanism for experience-dependent reorganization of cortical neural circuits, we used mutant mice which have impairment of hearing. Immunohisotochemical analysis for fos protein which is activity dependently expressed in neurons were performed. We found that fos-expressing neurons in auditory cortex of mutant mice were more frequent than that of naive mice. Furthermore, we found that acetylcholine and serotonin modulate the cortical activity by the facilitation or the depression during exploration and stationary state, respectively.

Free Research Field

神経回路網