2013 Fiscal Year Final Research Report
Analysis of cholinergic neurons derived from Alzheimer's disease patient-specific iPS cells
| Project/Area Number |
24700367
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | Fujita Health University (2013)
Kyoto University (2012) |
|---|
Principal Investigator |
YAHATA Naoki 藤田保健衛生大学, 医学部, 助教 (60450607)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | アルツハイマー病 / iPS細胞 |
|---|
| Research Abstract |
We have generated disease-specific iPS cells from familial Alzheimer's disease patients with Presenilin 1 mutations (AD-iPSCs). AD or control iPSCs were differentiated into cortical neurons mainly containing glutamatergic neurons. The production ratio of the pathogenic amyloid beta species was increased in AD-neurons. Microarray analysis of purified neurons revealed distinct gene expression profiles between AD and control neurons.
|
Research Products
(8 results)
